10-я хромосома человека - одна из хромосом человеческого генома. Содержит около 135 млн. пар оснований и составляет от 4% до 4.5% клеточного материала ДНК. По разным оценкам, содержит от 800 до 1200 генов.
Гены
Ниже приведены некоторые известные гены, расположенные на 10-й хромосоме человека:
- ALOX5 — Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response; also facilitates development and maintenance of cancer stem cells, slow-dividing cells thought to give rise to a variety of cancers, including leukemia);
- CDH23 — cadherin-like 23;
- CXCL12 — chemokine (C-X-C motif) ligand 12, SDF-1, scyb12;
- EGR2 — early growth response 2 (Krox-20 homolog, Drosophila);
- ERCC6 — excision repair cross-complementing rodent repair deficiency, complementation group 6;
- FGFR2 — fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome);
- NRP1 — нейропилин 1;
- PCBD1 — 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);
- PCDH15 — protocadherin 15;
- PTEN gene — phosphatase and tensin homolog (mutated in multiple advanced cancers 1);
- RET — ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease);
- VIM — виментин;
- UROS — uroporphyrinogen III synthase (congenital erythropoietic porphyria).
q-плечо
p-плечо